Piper species are aromatic plants used as spices in the kitchen, but their secondary
metabolites have also shown biological effects on human health. These plants are rich in …

Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

Abstract Background Black pepper [Piper nigrum (L.), Family: Piperaceae] is used
traditionally for the treatment of various diseases including; cough, cold, dyspnea throat …

Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …

Plants are vital for the wellbeing of humankind in a variety of ways. Some plant extracts
contain antimicrobial properties that can treat different pathogens. Most of the world's …

A mouse model of depression has been recently developed by exogenous corticosterone
(CORT) administration, which has shown to mimic HPA-axis induced depression-like state in …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-
orientated, single target, and conventional antidepressants are insufficient and far from …

Previous researches found that apigenin exerted antidepressant-like effects in rodents.
However, it is unclear whether the neurotrophic system is involved in the antidepressant-like …

Age-related neurological disorders (ANDs), including neurodegenerative diseases, are
multifactorial disorders whose risk increases with age. The main pathological hallmarks of …