The safety of blood transfusion is still threatened by contamination of blood products with a
variety of pathogens such as viruses, bacteria and parasites. A novel pathogen reduction …

D URING THE PAST 2 decades, the demand for platelet concentrates (PC) has been
steadily increasing because of more intense treatment schedules as well as widening …

A platelet gel (PG) is produced by the addition of calcium chloride and thrombin to a platelet
concentrate (PC). PG releases multiple growth factors, which have the ability to initiate and …

Rapid chilling causes glycoprotein-Ib (GPIb) receptors to cluster on blood platelets. Hepatic
macrophage β2 integrin binding to β-N-acetylglucosamine (β-GlcNAc) residues in the …

BACKGROUND: A photochemical treatment process has been developed for the
inactivation of viruses and bacteria in platelet concentrates. This process is based on the …

The ability to create a platelet product for transfusion purposes has existed for more than 50
years, 1 and has contributed to fundamental changes in the practice of transfusion medicine …

Objective: The aim of the study was to compare the clinical effects and hemostatic efficiency
of transfusions of platelets preserved in the frozen state for as long as 2 years with …

Three different separation methods, all using centrifugation, are routinely used to prepare
therapeutic platelet concentrates from human donor blood. Platelet concentrates derived …

Since 1990, several techniques have been developed to photochemically inactivate
pathogens in platelet concentrates, potentially leading to safer transfusion therapy. The …

BACKGROUND: Platelets possess some of the machinery required for apoptotic cell death.
However, disruption of mitochondria function, implicated in several models of cell death, has …