Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

Fibrosis is the final common pathway of inflammatory diseases in various organs. The
inflammasomes play an important role in the progression of fibrosis as innate immune …

Ovarian cancer (OC) is a highly malignant gynaecological tumour that has a very poor
prognosis. Pyroptosis has been demonstrated in recent years to be an inflammatory form of …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …

Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …

Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns
(PAMPs), which are molecular signatures shared by different pathogens. Recognition of …