A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins

J Liao, Y Wei, J Liang, J Wen, X Chen, B Zhang… - Cell death …, 2022 - nature.com
Abstract YT521-B homology (YTH) domain-containing proteins (YTHDF1-3, YTHDC1-2) are
the most crucial part of N6-methyladenosine (m6A) readers and play a regulatory role in …

YTHDC1 m6A-dependent and m6A-independent functions converge to preserve the DNA damage response

D Elvira-Blázquez, JM Fernández-Justel… - The EMBO …, 2024 - embopress.org
Cells have evolved a robust and highly regulated DNA damage response to preserve their
genomic integrity. Although increasing evidence highlights the relevance of RNA regulation …

A classical revival: Human satellite DNAs enter the genomics era

N Altemose - Seminars in cell & developmental biology, 2022 - Elsevier
The classical human satellite DNAs, also referred to as human satellites 1, 2 and 3 (HSat1,
HSat2, HSat3, or collectively HSat1–3), occur on most human chromosomes as large …

Satellite RNAs: emerging players in subnuclear architecture and gene regulation

K Ninomiya, T Yamazaki, T Hirose - The EMBO journal, 2023 - embopress.org
Satellite DNA is characterized by long, tandemly repeated sequences mainly found in
centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to …

Nucleolar-and Nuclear-Stress-Induced Membrane-Less Organelles: A Proteome Analysis through the Prism of Liquid–Liquid Phase Separation

YI Mokin, AA Gavrilova, AS Fefilova… - International Journal of …, 2023 - mdpi.com
Radical changes in the idea of the organization of intracellular space that occurred in the
early 2010s made it possible to consider the formation and functioning of so-called …

Centromeric and pericentric transcription and transcripts: their intricate relationships, regulation, and functions

J Zhu, Q Guo, M Choi, Z Liang, KWY Yuen - Chromosoma, 2023 - Springer
Centromeres are no longer considered to be silent. Both centromeric and pericentric
transcription have been discovered, and their RNA transcripts have been characterized and …

Splicing regulation through biomolecular condensates and membraneless organelles

J Giudice, H Jiang - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

R Vaid, K Thombare, A Mendez… - Nucleic Acids …, 2024 - academic.oup.com
Telomerase-negative tumors maintain telomere length by alternative lengthening of
telomeres (ALT), but the underlying mechanism behind ALT remains poorly understood. A …

[HTML][HTML] Multi-color RNA imaging with CRISPR-Cas13b systems in living cells

LZ Yang, BQ Gao, Y Huang, Y Wang, L Yang, LL Chen - Cell Insight, 2022 - Elsevier
Visualizing RNA dynamics is important for understanding RNA function. Catalytically dead
(d) CRISPR-Cas13 systems have been established to image and track RNAs in living cells …