Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …

Eukaryotic genomes are compacted into loops and topologically associating domains
(TADs),–, which contribute to transcription, recombination and genomic stability,. Cohesin …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

The frequency of egg aneuploidy and trisomic pregnancies increases with maternal age. To
what extent individual approaches can delay the" maternal age effect" is unclear because …

The cohesin complex plays essential roles in chromosome segregation, 3D genome
organisation, and DNA damage repair through its ability to modify DNA topology. In higher …

Meiosis is critically different from mitosis in that during meiosis, pairing and segregation of
homologous chromosomes occur. During meiosis, the morphology of sister chromatids …

ABSTRACT REC8 meiotic recombination protein (REC8) is a member of structural
maintenance of chromosome (SMC) protein partners, which play an important role in …

After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of
a new life. Then the embryonic development is monitored and regulated precisely from the …