Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common
cause of dementia in the elderly. Current consensus statements have emphasized the need …

We reviewed the literature of proton magnetic resonance spectroscopy (MRS) in dementia
and Parkinson's disease (PD) and quantitatively compared the reported values of the …

Objective: To determine whether serum trace metals and oxidative species are related to
abnormal cognition in AD. Methods: The authors studied serum peroxides, copper, iron …

BACKGROUND AND PURPOSE: Aging is recognized to originate from a diversity of
mechanisms that blur the limits between normal and pathologic processes. The purpose of …

Quantitative measurements of regional and tissue specific concentrations of brain
metabolites were measured in elderly subjects using multislice proton magnetic resonance …

Background: Both AD and normal aging cause brain atrophy, limiting the ability of MRI to
distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures …

The authors have previously reported decreased intracellular pH (pHi) in the frontal lobes in
euthymic bipolar patients treated with lithium using 31 P-MRS. White matter hyperintensity …

The emergence of sensitive techniques for brain imaging has drawn attention to the
occurrence of diffuse or multifocal changes affecting the cerebral white matter. The white …

Proton magnetic resonance spectroscopy (1H-MRS) allows major metabolites to be
measured noninvasively in defined regions of the living brain, and can detect biochemical …

Microangiopathic end-organ injury is common in type 1 diabetes. However, the
pathophysiology of diabetic encephalopathy is poorly understood. The authors studied 10 …