Base and nucleotide excision repair (BER and NER) pathways are normally associated with
removal of specific types of DNA damage: small base modifications (such as those induced …

The base excision repair (BER) pathway historically has been associated with maintaining
genome integrity by eliminating nucleobases with small chemical modifications. In the past …

Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent
determined by activity of the DNA damage response (DDR). Combining chemotherapy with …

The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base
lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in …

Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

Abstract The N-(2-deoxy-d-erythro-pentofuranosyl)-urea DNA lesion forms following
hydrolytic fragmentation of cis-5 R, 6 S-and trans-5 R, 6 R-dihydroxy-5, 6-dihydrothymidine …

Endonuclease VIII-like (NEIL) 1 and 3 proteins eliminate oxidative DNA base damage and
psoralen DNA interstrand crosslinks through initiation of base excision repair. Current …

Interstrand DNA-DNA cross-links (ICLs) are generated by endogenous processes, drugs,
and environmental toxins. Understanding the cellular pathways by which various ICLs are …

DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork
progression. ICL accumulation results in growth arrest and cell death—particularly in cell …

Abstract The NTHL1 and NEIL1-3 DNA glycosylases are major enzymes in the removal of
oxidative DNA base lesions, via the base excision repair (BER) pathway. It is expected that …