Migraine is ranked as a leading cause of years lived with disability among all neurological
disorders. Therapies targeting the calcitonin gene-related peptide (CGRP) signaling …

Headache disorders can produce recurrent, incapacitating pain. Migraine and cluster
headache are notable for their ability to produce significant disability. The anatomy and …

Migraine is one of the most common neurological illnesses, and it is characterized by
complicated neurobiology. It was confirmed the influence of inflammation and oxidative …

Background Migraine is a highly disabling health burden with multiple symptoms; however,
it remains undertreated because of an inadequate understanding of its neural mechanisms …

Background Migraine headaches have been associated with sensory hyperactivity and
anomalies in social/emotional responses. The main objective of this study was to evaluate …

Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and
other associated symptoms. Emotional-affective aspects are important components of pain …

Abstract Orexin 1 receptors (Orx1R) and cannabinoid 1 receptors (CB1R) are implicated in
migraine pathophysiology. This study evaluated the potential involvement of Orx1R and …

Electroacupuncture (EA) is widely used in clinical practice to relieve migraine pain. 5-HT7
receptor (5-HT7R) has been reported to play an excitatory role in neuronal systems and …

Central sensitization is an important pathophysiological mechanism underlying chronic
migraine (CM). Previous studies have shown that microglial activation and subsequent …

Background Neuropeptides play a critical role in regulating pain and inflammation. Despite
accumulating evidence has further uncovered the novel functions and mechanisms of …