Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

Purpose: Radiation exposure triggers a complex network of molecular and cellular
responses that impacts metabolic processes and alters the levels of metabolites. Such …

The tear film overlying the epithelial cells of the eye's surface is vital to visual function, and
its composition is reflective of ocular surface health. The ultrasmall volume of tears poses …

Background Space travel is associated with continuous low dose rate exposure to high
linear energy transfer (LET) radiation. Pathophysiological manifestations after low dose …

Human exposure to ionizing radiation (IR) disrupts normal metabolic processes in cells and
organs by inducing complex biological responses that interfere with gene and protein …

Modulating tissue responses to stress is an important therapeutic objective. Oxidative and
genotoxic stresses caused by ionizing radiation are detrimental to healthy tissues but …

Exposure to ionizing radiation induces a cascade of molecular events that ultimately impact
endogenous metabolism. Qualitative and quantitative characterization of metabolomic …

Recently, various approaches have been addressed to improve chromatographic
performance in terms of sensitivity or selectivity, from the development of novel on-line (or off …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common form of cancer
worldwide. Radiotherapy, with or without surgery, represents the major approach to curative …

Dietary factors modulate interactions between the microbiome, metabolome, and immune
system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin …