Changing patterns in the epidemiology of β‐thalassemia

A Kattamis, GL Forni, Y Aydinok… - European Journal of …, 2020 - Wiley Online Library
Abstract β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red
blood cell transfusions and iron chelation therapy to prevent complications due to iron …

[HTML][HTML] A paradigm shift on beta-thalassaemia treatment: How will we manage this old disease with new therapies?

MD Cappellini, JB Porter, V Viprakasit, AT Taher - Blood reviews, 2018 - Elsevier
Beta-thalassaemia causes defective haemoglobin synthesis leading to ineffective
erythropoiesis, chronic haemolytic anaemia, and subsequent clinical complications. Blood …

[HTML][HTML] A systematic review and meta-analysis of stature growth complications in β-thalassemia major patients

M Arab-Zozani, S Kheyrandish, A Rastgar… - Annals of global …, 2021 - ncbi.nlm.nih.gov
Background: Blood transfusion is a traditional treatment for β-thalassemia (β-thal) that
improves the patients' anemia and lifespan, but it may lead to iron overload in parenchymal …

[HTML][HTML] Thalassemia: A Review of the Challenges to the Families and Caregivers

R Yousuf, S Akter, SM Wasek, S Sinha, R Ahmad… - Cureus, 2022 - ncbi.nlm.nih.gov
Thalassemias are a group of congenital hemoglobin (Hb) disorders distinguished by
dwindling or total curtailment of production of one or more globin chains of hemoglobin …

Relationship between serum ferritin and outcomes in β-thalassemia: a systematic literature review

F Shah, K Huey, S Deshpande, M Turner… - Journal of Clinical …, 2022 - mdpi.com
Among the difficulties of living with β-thalassemia, patients frequently require blood
transfusions and experience iron overload. As serum ferritin (SF) provides an indication of …

Global burden and unmet needs in the treatment of transfusion-dependent β-thalassemia

GL Forni, G Grazzini, J Boudreaux, V Agostini… - Frontiers in …, 2023 - frontiersin.org
Beta thalassemia (β-thalassemia) is part of a group of inherited hemoglobinopathies caused
by a mutation in the beta globin gene, leading to minimal functional hemoglobin and …

Predictors of health state utility values using SF-6D for Chinese adult patients with β-thalassemia major

R Zhang, S Zhang, J Ming, J Xie, B Liu… - Frontiers in Public …, 2023 - frontiersin.org
Background Patients with β-thalassemia major (β-TM), predominantly adult patients, are
associated with physical, mental, and social problems, that result in decreased quality of life …

[HTML][HTML] Thalassemia major: transplantation or transfusion and chelation

SY Mohamed - Hematology/Oncology and Stem Cell Therapy, 2017 - Elsevier
Thalassemia is the most common monogenic hematologic disease that affects millions in the
world and kills thousands of patients every year. Without transfusion or transplantation …

Quality of life (QoL) and the factors affecting it in transfusion-dependent thalassemic children

K Chordiya, V Katewa, P Sharma, B Deopa… - The Indian Journal of …, 2018 - Springer
Abstract Objectives To evaluate the Quality of life (QoL) and the factors affecting it in
transfusion-dependent thalassemic children. Methods Current study was conducted at …

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta thalassaemia

ZA Padhani, MK Gangwani, A Sadaf… - Cochrane Database …, 2023 - cochranelibrary.com
Background Beta‐thalassaemia is an inherited blood disorder that reduces the production of
haemoglobin. The most severe form requires recurrent blood transfusions, which can lead to …