Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

S Chatterjee, A Mudher - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

Inflammatory cytokines and Alzheimer's disease: a review from the perspective of genetic polymorphisms

F Su, F Bai, Z Zhang - Neuroscience bulletin, 2016 - Springer
Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which
microglia are over-activated, resulting in the increased production of pro-inflammatory …

CD33 in Alzheimer's disease–biology, pathogenesis, and therapeutics: a mini-review

L Zhao - Gerontology, 2019 - karger.com
Alzheimer's disease (AD) affects nearly 50 million people worldwide, and currently no
disease-modifying treatment is available. With continuous failure of anti-amyloid-beta-or tau …

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

LM Tai, S Ghura, KP Koster, V Liakaite… - Journal of …, 2015 - Wiley Online Library
Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ)
contribute to Alzheimer's disease (AD) pathology. APOE 4 is the greatest AD‐genetic risk …

Friend, foe or both? Immune activity in Alzheimer's disease

GR Frost, LA Jonas, YM Li - Frontiers in Aging Neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques,
neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the …

Shifting equilibriums in Alzheimer's disease: The complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis

SC Gray, KJ Kinghorn, NS Woodling - Neural Regeneration …, 2020 - journals.lww.com
Alzheimer's disease is the leading cause of dementia. Its increased prevalence in
developed countries, due to the sharp rise in ageing populations, presents one of the …

Early life stress and epigenetics in late-onset Alzheimer's dementia: a systematic review

E Lemche - Current genomics, 2018 - ingentaconnect.com
Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer's disease

C Gao, X Shen, Y Tan, S Chen - Journal of Neuroinflammation, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease and the most
common cause of dementia. Among various pathophysiological aspects, microglia are …

Circulating vitamin E levels and Alzheimer's disease: a Mendelian randomization study

G Liu, Y Zhao, S Jin, Y Hu, T Wang, R Tian, Z Han… - Neurobiology of …, 2018 - Elsevier
Alzheimer's disease (AD) is the leading cause of dementia in older adults. It is more than 50
years since vitamin E was recognized as critical for optimal neurological health. Clinical …

Does the CD33 rs3865444 Polymorphism Confer Susceptibility to Alzheimer's Disease?

V Siokas, P Aslanidou, AM Aloizou, E Peristeri… - Journal of Molecular …, 2020 - Springer
Alzheimer's disease (AD) is a complex genetic disorder. To date, published data have
reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present …