A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

The accumulation of abnormal protein aggregates represents a universal hallmark of
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …

The aggregation of proteins into amyloid-like fibrils is seen in many neurodegenerative
diseases. Recent years have seen much progress in our understanding of these misfolded …

Herein, we used protein semisynthesis to investigate, for the first time, the effect of lysine
acetylation and phosphorylation, as well as the crosstalk between these modifications on the …

Neurodegenerative diseases (NDs) are a cluster of diseases marked by progressive
neuronal loss, axonal transport blockage, mitochondrial dysfunction, oxidative stress …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Huntington disease (HD) is an ideal model for investigating selective neurodegeneration, as
expanded polyQ repeats in the ubiquitously expressed huntingtin (HTT) cause the …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder
characterized by the loss of motor control and cognitive ability, which eventually leads to …