Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …

To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry …

Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …

Authorized vaccines against SARS-CoV-2 remain less available in low-and middle-income
countries due to insufficient supply, high costs, and storage requirements. Global immunity …

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …

Developing affordable and easily manufactured SARS-CoV-2 vaccines will be essential to
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …

Computationally designed protein nanoparticles have recently emerged as a promising
platform for the development of new vaccines and biologics. For many applications …

Recombinant protein approaches offer major promise for safe and effective vaccine
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …

SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …