A biosensor is an analytical device that can be used for detecting analytes and combines a
biological component with a physicochemical detecting transducer. In recent years …

Ion channels represent highly attractive targets for drug discovery and are implicated in a
diverse range of disorders, in particular in the central nervous and cardiovascular systems …

Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity
on the basis of the binding mode of albaconazole using molecular docking, along with SAR …

Inhibition of methionine adenosyltransferase 2A (MAT2A) in cancers with a deletion of
methylthioadenosine phosphorylase (MTAP) gene leads to synthetic lethality, thus receiving …

There is no doubt that automated patch clamp (APC) technology has revolutionized
research in biomedical science. High throughput ion channel screening is now an integral …

Many ion channels are recognized as amenable targets for a range of disease states and
conditions. However, the process of discovering drugs is highly influenced by the chemical …

Ion channels represent a class of membrane spanning protein pores that mediate the flux of
ions in a variety of cell types. To date,> 400 ion channels have been cloned and …

In silico approaches are widely used to predict human ether-a-go-go-related gene (hERG)
channel blockade. Published pharmacophore models of hERG blockers typically contain a …

Covering: 1996–December 2016 The human Ether-à-go-go Related Gene (hERG) channel
is a voltage-gated potassium channel playing an essential role in the normal electrical …

To generate the desired effect in the human body, the active pharmaceutical ingredient
usually needs to interact with a receptor located on the cell membrane or inside the cell …