[HTML][HTML] Vasoplegia treatments: the past, the present, and the future
B Levy, C Fritz, E Tahon, A Jacquot, T Auchet… - Critical care, 2018 - Springer
Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic,
cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving …
cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving …
Sepsis‐induced acute kidney injury: a disease of the microcirculation
S Ma, RG Evans, N Iguchi, M Tare… - …, 2019 - Wiley Online Library
AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …
[HTML][HTML] The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care …
Background Septic shock is associated with decreased vasopressor responsiveness.
Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) …
Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) …
The effect of propofol and dexmedetomidine sedation on norepinephrine requirements in septic shock patients: a crossover trial
A Morelli, F Sanfilippo, P Arnemann… - Critical care …, 2019 - journals.lww.com
Objectives: Propofol-based sedation may increase hemodynamic instability by decreasing
vascular tone and venous return. Incremental exogenous catecholamines doses may be …
vascular tone and venous return. Incremental exogenous catecholamines doses may be …
[HTML][HTML] Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care
F Sanfilippo, S Scolletta, A Morelli… - Annals of intensive …, 2018 - Springer
There is growing evidence both in the perioperative period and in the field of intensive care
(ICU) on the association between left ventricular diastolic dysfunction (LVDD) and worse …
(ICU) on the association between left ventricular diastolic dysfunction (LVDD) and worse …
Emerging benefits and drawbacks of α2‐adrenoceptor agonists in the management of sepsis and critical illness
Agonists of α2‐adrenoceptors are increasingly being used for the provision of comfort,
sedation and the management of delirium in critically ill patients, with and without sepsis. In …
sedation and the management of delirium in critically ill patients, with and without sepsis. In …
[HTML][HTML] The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies
CA Flanders, AS Rocke, SA Edwardson, JK Baillie… - Critical Care, 2019 - Springer
Background The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs
during critical illness. These drugs may have anti-inflammatory effects, which might be …
during critical illness. These drugs may have anti-inflammatory effects, which might be …
[HTML][HTML] Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep
N Iguchi, J Kosaka, LC Booth, Y Iguchi… - British journal of …, 2019 - Elsevier
Background Global and intra-renal perfusion and oxygenation may be affected by the choice
of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on …
of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on …
[HTML][HTML] Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury
YR Lankadeva, S Ma, N Iguchi, RG Evans, SG Hood… - Kidney international, 2019 - Elsevier
Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney
injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore …
injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore …
Renal medullary hypoxia: a new therapeutic target for septic acute kidney injury?
Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …