Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the
incidence of liver disease is dramatically rising due to the aging of the population and the …

Regulated mRNA translation plays an important role in normal cellular functions and
cytoplasmic polyadenylation element binding proteins (CPEBs) are the key factors that …

Memory consolidation theory suggests that once memory formation has been completed,
memory is maintained at a stable strength and is incapable of further enhancement …

Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting
synaptic modifications and consolidate memory. We investigated the role of the translational …

Triple negative breast cancer (TNBC) represents an anomalous subset of breast cancer with
a greatly reduced (30%) 5-year survival rate. The enhanced mortality and morbidity of TNBC …

Long-term memory (LTM) formation relies on de novo protein synthesis; however, the full
complement of proteins crucial to LTM formation remains unknown in any system. Using an …

The tumor suppressor p53 transactivates the expression of multiple genes to exert its
multifaceted functions and ultimately maintains genome stability. Thus, cancer cells develop …

Background Over-expression of cyclooxygenase (COX)-2 promotes breast cancer
progression by multiple mechanisms, including induction of stem-like cells (SLC). Combined …

Background Local translation at synapses is important for rapidly remodeling the synaptic
proteome to sustain long-term plasticity and memory. While the regulatory mechanisms …

Oocyte meiotic maturation and embryogenesis are some of the most important physiological
processes that occur in organisms, playing crucial roles in the preservation of life in all …