Deuterostomes are the major division of animal life which includes sea stars, acorn worms,
and humans, among a wide variety of ecologically and morphologically disparate taxa …

Animals have evolved a multitude of signaling pathways that enable them to orchestrate
diverse physiological processes to tightly regulate systemic homeostasis. This signaling is …

CP190 is a co-factor in many Drosophila architectural proteins, being involved in the
formation of active promoters and insulators. CP190 contains the N-terminal BTB/POZ …

The gastrointestinal (GI) tract is complex and consists of multiple organs with unique
functions. Rare gene variants can cause congenital malformations of the human GI tract …

Few other invertebrates captivate our attention as cephalopods do. Octopods, cuttlefish, and
squids amaze with their behavior and sophisticated body plans that belong to the most …

Hox gene clusters encode transcription factors that drive regional specialization during
animal development: for example the Hox factor Ubx is expressed in the insect metathoracic …

Metazoans differentially express multiple Hox transcription factors to specify diverse cell
fates along the developing anterior-posterior axis. Two challenges arise when trying to …

Anaplastic thyroid carcinoma (ATC) is a deadly disease with a poor prognosis. Thus, there is
a pressing need to determine the mechanism of ATC progression. The homeobox D9 …

Cell fate decisions remain poorly understood at the molecular level. Embryogenesis
provides a unique opportunity to analyze molecular details associated with cell fate …

Endometrial cancer is the fourth most common malignancy in women and the precursor
lesion is endometrial hyperplasia. HOXA10 is a transcription factor that plays key roles in …