Erythropoietic regulators of iron metabolism

T Ganz - Free Radical Biology and Medicine, 2019 - Elsevier
Erythropoiesis is the predominant consumer of iron in humans and other vertebrates. By
decreasing the transcription of the gene encoding the iron-regulatory hormone hepcidin …

The biology of mammalian multi-copper ferroxidases

SL Helman, J Zhou, BK Fuqua, Y Lu, JF Collins… - Biometals, 2023 - Springer
The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH)
and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron …

How I treat cancer-associated anemia

JA Gilreath, GM Rodgers - Blood, The Journal of the American …, 2020 - ashpublications.org
Despite increasing use of targeted therapies to treat cancer, anemia remains a common
complication of cancer therapy. Physician concerns about the safety of intravenous (IV) iron …

The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis

H Kawabata - International journal of hematology, 2018 - Springer
Hereditary hemochromatosis (HH) is a group of genetic iron overload disorders that manifest
with various symptoms, including hepatic dysfunction, diabetes, and cardiomyopathy …

[HTML][HTML] Effect of functional beetroot pomace biscuit on phenylhydrazine induced anemia in albino rats: Hematological and blood biochemical analysis

EM Abdo, OES Shaltout, S El-Sohaimy… - Journal of Functional …, 2021 - Elsevier
The present study incorporated beetroot pomace powder in biscuit preparation at
concentrations of 5–20%. Biscuits' chemical composition, and sensory were evaluated. A …

Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia

LFV Furtado, WP Alves, VJ da Silva, ÉML Rabelo - Cytokine, 2024 - Elsevier
Over the years, there has been progress in understanding the molecular aspects of iron
metabolism and erythropoiesis. However, despite research conducted both in laboratories …

Molecular perspective of iron uptake, related diseases, and treatments

N Shokrgozar, HA Golafshan - Blood research, 2019 - synapse.koreamed.org
Iron deficiency anemia and anemia of chronic disorders are the most common types of
anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron …

The relationship between systemic iron homeostasis and erythropoiesis

G Rishi, VN Subramaniam - Bioscience reports, 2017 - portlandpress.com
Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body;
this need is satisfied by maintaining a sensitive regulation of iron levels. The level of …

Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia

FM El Gendy, MA EL‐Hawy… - European journal of …, 2018 - Wiley Online Library
Objectives To investigate the link between serum erythroferrone (ERFE) levels and iron
status parameters in pediatric patients with iron deficiency anemia. Methods The study …

Characterization of Erythroferrone in a Teleost Fish (Dicentrarchus labrax) With Two Functional Hepcidin Types: More Than an Erythroid Regulator

JV Neves, C Barroso, P Carvalho, M Nunes… - Frontiers in …, 2022 - frontiersin.org
Erythroferrone is a recently identified erythroid regulator produced by erythroblasts in the
mammalian bone marrow and extramedullary sites, known to be induced in conditions of …