Cellular functions of long noncoding RNAs
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …
are transcribed from the mammalian genome. They are emerging as important regulators in …
Nuclear long noncoding RNAs: key regulators of gene expression
A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
Nuclear m6A reader YTHDC1 regulates mRNA splicing
The regulatory role of N 6-methyladenosine (m 6 A) and its nuclear binding protein YTHDC1
in pre-mRNA splicing remains an enigma. Here we show that YTHDC1 promotes exon …
in pre-mRNA splicing remains an enigma. Here we show that YTHDC1 promotes exon …
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can
be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with …
be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with …
Nuclear speckles: molecular organization, biological function and role in disease
L Galganski, MO Urbanek… - Nucleic acids …, 2017 - academic.oup.com
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Abstract The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …
Context-dependent control of alternative splicing by RNA-binding proteins
XD Fu, M Ares Jr - Nature Reviews Genetics, 2014 - nature.com
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
MALAT1 Long Non-Coding RNA: Functional Implications
The mammalian genome is pervasively transcribed and the functional significance of many
long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis …
long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis …
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Recent molecular studies have shown that, even when derived from a seemingly
homogenous population, individual cells can exhibit substantial differences in gene …
homogenous population, individual cells can exhibit substantial differences in gene …