Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …

Cancer metastasis accounts for the major cause of cancer-related deaths. How
disseminated cancer cells cope with hostile microenvironments in secondary site for full …

Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the
production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to …

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …

Abstract Background PI3K/AKT is a vital signaling pathway in humans. Recently, several
PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance …

The critical factors for regulating cancer metabolism are oxidative stress and
phosphoinositide-3-kinase/AKT serine-threonine kinase/mechanistic target of the rapamycin …

Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the
suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted …

Background Cancer management faces multiple obstacles, including resistance to current
therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt …

Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited
understanding of brain metastasis tumor and immune biology, drivers of resistance to …