The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis

SS Das, P Bharadwaj, M Bilal, M Barani, A Rahdar… - Polymers, 2020 - mdpi.com
In the past few decades, polymeric nanocarriers have been recognized as promising tools
and have gained attention from researchers for their potential to efficiently deliver bioactive …

Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

JJ Li, Y Hu, B Hu, W Wang, H Xu, XY Hu, F Ding… - Nature …, 2022 - nature.com
Diabetic wound is one of the most intractable chronic wounds that is prone to bacterial
infection. Hypoxia is an important feature in its microenvironment. However, it is challenging …

Molecular engineering to boost AIE‐active free radical photogenerators and enable high‐performance photodynamic therapy under hypoxia

Q Wan, R Zhang, Z Zhuang, Y Li… - Advanced Functional …, 2020 - Wiley Online Library
The severe hypoxia in solid tumors and the vicious aggregation‐caused fluorescence
quenching (ACQ) of conventional photosensitizers (PSs) have limited the application of …

Revisiting fluorescent calixarenes: from molecular sensors to smart materials

R Kumar, A Sharma, H Singh, P Suating… - Chemical …, 2019 - ACS Publications
Calix [n] arenes (n= 4, 5, 6, 8) are “chalicelike” phenol-based macrocycles that are among
the most fascinating and highly studied scaffolds in supramolecular chemistry. This stems …

Red-light-triggered self-destructive mesoporous silica nanoparticles for cascade-amplifying chemo-photodynamic therapy favoring antitumor immune responses

Y Yang, F Chen, N Xu, Q Yao, R Wang, X Xie, F Zhang… - Biomaterials, 2022 - Elsevier
Although chemo-photodynamic therapy demonstrates promising synergetic therapeutic
effects in malignant tumors, the light-controlled drug release, synergism and biocompatibility …

Hypoxia-targeted drug delivery

A Sharma, JF Arambula, S Koo, R Kumar… - Chemical Society …, 2019 - pubs.rsc.org
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Superoxide radical photogenerator with amplification effect: surmounting the achilles' heels of photodynamic oncotherapy

M Li, T Xiong, J Du, R Tian, M Xiao, L Guo… - Journal of the …, 2019 - ACS Publications
Strong oxygen dependence, poor tumor targeting, and limited treatment depth have been
considered as the “Achilles' heels” facing the clinical usage of photodynamic therapy (PDT) …

A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement

L Ge, Y Tang, C Wang, J Chen, H Mao… - Nature …, 2024 - nature.com
While performing oxygen-related tumour treatments such as chemotherapy and
photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and …

Microenvironment of pancreatic inflammation: calling for nanotechnology for diagnosis and treatment

L Liu, Y Zhang, X Li, J Deng - Journal of Nanobiotechnology, 2023 - Springer
Acute pancreatitis (AP) is a common and life-threatening digestive disorder. However, its
diagnosis and treatment are still impeded by our limited understanding of its etiology …