The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis
In the past few decades, polymeric nanocarriers have been recognized as promising tools
and have gained attention from researchers for their potential to efficiently deliver bioactive …
and have gained attention from researchers for their potential to efficiently deliver bioactive …
Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer
JJ Li, Y Hu, B Hu, W Wang, H Xu, XY Hu, F Ding… - Nature …, 2022 - nature.com
Diabetic wound is one of the most intractable chronic wounds that is prone to bacterial
infection. Hypoxia is an important feature in its microenvironment. However, it is challenging …
infection. Hypoxia is an important feature in its microenvironment. However, it is challenging …
Molecular engineering to boost AIE‐active free radical photogenerators and enable high‐performance photodynamic therapy under hypoxia
Q Wan, R Zhang, Z Zhuang, Y Li… - Advanced Functional …, 2020 - Wiley Online Library
The severe hypoxia in solid tumors and the vicious aggregation‐caused fluorescence
quenching (ACQ) of conventional photosensitizers (PSs) have limited the application of …
quenching (ACQ) of conventional photosensitizers (PSs) have limited the application of …
Revisiting fluorescent calixarenes: from molecular sensors to smart materials
Calix [n] arenes (n= 4, 5, 6, 8) are “chalicelike” phenol-based macrocycles that are among
the most fascinating and highly studied scaffolds in supramolecular chemistry. This stems …
the most fascinating and highly studied scaffolds in supramolecular chemistry. This stems …
Red-light-triggered self-destructive mesoporous silica nanoparticles for cascade-amplifying chemo-photodynamic therapy favoring antitumor immune responses
Y Yang, F Chen, N Xu, Q Yao, R Wang, X Xie, F Zhang… - Biomaterials, 2022 - Elsevier
Although chemo-photodynamic therapy demonstrates promising synergetic therapeutic
effects in malignant tumors, the light-controlled drug release, synergism and biocompatibility …
effects in malignant tumors, the light-controlled drug release, synergism and biocompatibility …
Hypoxia-targeted drug delivery
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …
associated with abnormal vasculature, which results in a reduced supply of oxygen and …
Superoxide radical photogenerator with amplification effect: surmounting the achilles' heels of photodynamic oncotherapy
M Li, T Xiong, J Du, R Tian, M Xiao, L Guo… - Journal of the …, 2019 - ACS Publications
Strong oxygen dependence, poor tumor targeting, and limited treatment depth have been
considered as the “Achilles' heels” facing the clinical usage of photodynamic therapy (PDT) …
considered as the “Achilles' heels” facing the clinical usage of photodynamic therapy (PDT) …
A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement
L Ge, Y Tang, C Wang, J Chen, H Mao… - Nature …, 2024 - nature.com
While performing oxygen-related tumour treatments such as chemotherapy and
photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and …
photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and …
Microenvironment of pancreatic inflammation: calling for nanotechnology for diagnosis and treatment
L Liu, Y Zhang, X Li, J Deng - Journal of Nanobiotechnology, 2023 - Springer
Acute pancreatitis (AP) is a common and life-threatening digestive disorder. However, its
diagnosis and treatment are still impeded by our limited understanding of its etiology …
diagnosis and treatment are still impeded by our limited understanding of its etiology …