Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …

Twenty-six new tacrine–benzofuran hybrids were designed, synthesized, and evaluated in
vitro on key molecular targets for Alzheimer's disease. Most hybrids exhibited good inhibitory …

Multi-target drug discovery is one of the most followed approaches in the active central
nervous system (CNS) therapeutic area, especially in the search for new drugs against …

Novel multifunctional tacrines for Alzheimer's disease were obtained by Ugi-reaction
between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine …

The therapy of complex neurodegenerative diseases requires the development of
multitarget‐directed drugs (MTDs). Novel indole derivatives with inhibitory activity towards …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …