Polycomb repressive complex 2 (PRC2) is a multisubunit protein complex essential for the
development of multicellular organisms. Recruitment of PRC2 to target genes, followed by …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …

F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth
defects of the central nervous system that originate during embryonic development when the …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

The chromatin environment is essential for the correct specification and preservation of cell
identity through modulation and maintenance of transcription patterns. Many chromatin …

Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene
repression. Organized within multiprotein complexes, they regulate developmental genes in …

Polycomb group (PcG) proteins play important roles in repressing lineage-specific genes
and maintaining the undifferentiated state of mouse embryonic stem cells (mESCs) …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …