Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Understanding nanoparticle cellular entry: a physicochemical perspective

CM Beddoes, CP Case, WH Briscoe - Advances in colloid and interface …, 2015 - Elsevier
Understanding interactions between nanoparticles (NPs) with biological matter, particularly
cells, is becoming increasingly important due to their growing application in medicine and …

CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans

J Lee, DS Patel, J Ståhle, SJ Park… - Journal of chemical …, 2018 - ACS Publications
Glycolipids (such as glycoglycerolipids, glycosphingolipids, and
glycosylphosphatidylinositol) and lipoglycans (such as lipopolysaccharides (LPS) …

[HTML][HTML] The basic structure and dynamics of cell membranes: An update of the Singer–Nicolson model

FM Goñi - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of
the cell membrane structure and dynamics. However a number of features, the result of four …

Ceramide: a simple sphingolipid with unique biophysical properties

BM Castro, M Prieto, LC Silva - Progress in lipid research, 2014 - Elsevier
Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …

[HTML][HTML] Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol

SL Veatch, SL Keller - Biophysical journal, 2003 - cell.com
We use fluorescence microscopy to directly observe liquid phases in giant unilamellar
vesicles. We find that a long list of ternary mixtures of high melting temperature (saturated) …

[HTML][HTML] Model systems, lipid rafts, and cell membranes

K Simons, WLC Vaz - Annu. Rev. Biophys. Biomol. Struct., 2004 - annualreviews.org
▪ Abstract Views of how cell membranes are organized are presently changing. The lipid
bilayer that constitutes these membranes is no longer understood to be a homogeneous …

[HTML][HTML] Seeing spots: complex phase behavior in simple membranes

SL Veatch, SL Keller - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2005 - Elsevier
Liquid domains in model lipid bilayers are frequently studied as models of raft domains in
cell plasma membranes. Micron-scale liquid domains are easily produced in vesicles …

Order of lipid phases in model and plasma membranes

HJ Kaiser, D Lingwood, I Levental… - Proceedings of the …, 2009 - National Acad Sciences
Lipid rafts are nanoscopic assemblies of sphingolipids, cholesterol, and specific membrane
proteins that contribute to lateral heterogeneity in eukaryotic membranes. Separation of …

Switchable nile red-based probe for cholesterol and lipid order at the outer leaflet of biomembranes

OA Kucherak, S Oncul, Z Darwich… - Journal of the …, 2010 - ACS Publications
Cholesterol and sphingomyelin form together a highly ordered membrane phase, which is
believed to play important biological functions in plasma membranes of mammalian cells …