Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Understanding nanoparticle cellular entry: a physicochemical perspective
CM Beddoes, CP Case, WH Briscoe - Advances in colloid and interface …, 2015 - Elsevier
Understanding interactions between nanoparticles (NPs) with biological matter, particularly
cells, is becoming increasingly important due to their growing application in medicine and …
cells, is becoming increasingly important due to their growing application in medicine and …
CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans
Glycolipids (such as glycoglycerolipids, glycosphingolipids, and
glycosylphosphatidylinositol) and lipoglycans (such as lipopolysaccharides (LPS) …
glycosylphosphatidylinositol) and lipoglycans (such as lipopolysaccharides (LPS) …
[HTML][HTML] The basic structure and dynamics of cell membranes: An update of the Singer–Nicolson model
FM Goñi - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of
the cell membrane structure and dynamics. However a number of features, the result of four …
the cell membrane structure and dynamics. However a number of features, the result of four …
Ceramide: a simple sphingolipid with unique biophysical properties
BM Castro, M Prieto, LC Silva - Progress in lipid research, 2014 - Elsevier
Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …
functions are thought to depend on ceramides' unique biophysical properties, which …
[HTML][HTML] Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol
We use fluorescence microscopy to directly observe liquid phases in giant unilamellar
vesicles. We find that a long list of ternary mixtures of high melting temperature (saturated) …
vesicles. We find that a long list of ternary mixtures of high melting temperature (saturated) …
[HTML][HTML] Model systems, lipid rafts, and cell membranes
K Simons, WLC Vaz - Annu. Rev. Biophys. Biomol. Struct., 2004 - annualreviews.org
▪ Abstract Views of how cell membranes are organized are presently changing. The lipid
bilayer that constitutes these membranes is no longer understood to be a homogeneous …
bilayer that constitutes these membranes is no longer understood to be a homogeneous …
[HTML][HTML] Seeing spots: complex phase behavior in simple membranes
Liquid domains in model lipid bilayers are frequently studied as models of raft domains in
cell plasma membranes. Micron-scale liquid domains are easily produced in vesicles …
cell plasma membranes. Micron-scale liquid domains are easily produced in vesicles …
Order of lipid phases in model and plasma membranes
HJ Kaiser, D Lingwood, I Levental… - Proceedings of the …, 2009 - National Acad Sciences
Lipid rafts are nanoscopic assemblies of sphingolipids, cholesterol, and specific membrane
proteins that contribute to lateral heterogeneity in eukaryotic membranes. Separation of …
proteins that contribute to lateral heterogeneity in eukaryotic membranes. Separation of …
Switchable nile red-based probe for cholesterol and lipid order at the outer leaflet of biomembranes
OA Kucherak, S Oncul, Z Darwich… - Journal of the …, 2010 - ACS Publications
Cholesterol and sphingomyelin form together a highly ordered membrane phase, which is
believed to play important biological functions in plasma membranes of mammalian cells …
believed to play important biological functions in plasma membranes of mammalian cells …