Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

The establishment and maintenance of apical‐basal polarity is a fundamental step in brain
development, instructing the organization of neural progenitor cells (NPCs) and the …

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …

The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

Background The intestine of children with severe malnutrition (SM) shows structural and
functional changes that are linked to increased infection and mortality. SM dysregulates the …

The study of human intestinal biology in healthy and diseased conditions has always been
challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro …

The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …

Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Gastrointestinal (GI) infections in sheep have significant implications for animal health,
welfare and productivity, as well as being a source of zoonotic pathogens. Interactions …