The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …

Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …

Dot1l is a histone methyltransferase without a SET domain and is responsible for H3K79
methylation, which marks active transcription. In contradiction, Dot1l also participates in …

Our ability to study early human post-implantation development remains highly limited due
to the ethical and technical challenges associated with intrauterine development of the …

Recent advances in synthetic embryology have opened new avenues for understanding the
complex events controlling mammalian peri-implantation development. Here, we show that …

The establishment of cellular identity is driven by transcriptional and epigenetic regulators of
the chromatin proteome-the chromatome. Comprehensive analyses of the chromatome …

Stem cells with the capacity of self-renewal and differentiation play pivotal roles in normal
tissues and malignant tumors. Whereas stem cells are supposed to be genetically identical …

Totipotency represents the highest developmental potency. By definition, totipotent stem
cells are capable of giving rise to all embryonic and extraembryonic cell types. In …