Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …

Various independent discoveries have shown that many organic codes exist in living
systems, and this implies that they came into being during the history of life and contributed …

Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes …

Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this
study, we identified the operative molecular mechanisms through which dynamic tensile …

Maintaining and modulating mechanical anisotropy is essential for biological processes.
However, how this is achieved at the microscopic scale in living soft matter is not always …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene expression, DNA replication and repair, chromosome condensation …

Abstract Systems Biology and the Modern Synthesis are recent versions of two classical
biological paradigms that are known as structuralism and functionalism, or internalism and …

Autophagy is an evolutionarily conserved catabolic process involved in several
physiological and pathological processes,. Although primarily cytoprotective, autophagy can …