Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

The classification of histamine receptors has to date been based on rigorous classical
pharmacological analysis, and as yet, the classification of the three histamine receptors that …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Imidazoles are an important class of heterocycles and include many substances of both
biological and chemical interest. They are part of a large number of highly significant …

Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …

Some G-protein-coupled receptors display 'constitutive activity', that is, spontaneous activity
in the absence of agonist,,,. This means that a proportion of the receptor population …

Histamine is a biogenic amine that participates in allergic and inflammatory processes by
stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic …

In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

Presynaptic H3 receptors occur on histaminergic neurones of the CNS (autoreceptors) and
on non‐histaminergic neurones of the central and autonomic nervous system …

Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and
cell differentiation in many organs, including the developing pancreas,. Here we show that …