Sepsis: pathophysiology and clinical management

JE Gotts, MA Matthay - Bmj, 2016 - bmj.com
Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Severe sepsis and septic shock

DC Angus, T Van der Poll - New England journal of medicine, 2013 - Mass Medical Soc
Severe Sepsis and Septic Shock | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Epidemiology of severe sepsis

FB Mayr, S Yende, DC Angus - Virulence, 2014 - Taylor & Francis
Severe sepsis is a leading cause of death in the United States and the most common cause
of death among critically ill patients in non-coronary intensive care units (ICU). Respiratory …

Mitigating inequities and saving lives with ICU triage during the COVID-19 pandemic

DB White, B Lo - American Journal of Respiratory and Critical Care …, 2021 - atsjournals.org
The burdens of the coronavirus disease (COVID-19) pandemic have fallen
disproportionately on disadvantaged groups, including the poor and Black, Latinx, and …

Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes

GS Martin - Expert review of anti-infective therapy, 2012 - Taylor & Francis
Sepsis has been around since the dawn of time, having been described for more than 2000
years, although clinical definitions are recent. The consensus sepsis definitions have …

Prescription of CRRT: a pathway to optimize therapy

A Karkar, C Ronco - Annals of intensive care, 2020 - Springer
Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is
associated with prolonged hospitalization, progression to chronic kidney disease (CKD) …

Population burden of long‐term survivorship after severe sepsis in older Americans

TJ Iwashyna, CR Cooke, H Wunsch… - Journal of the American …, 2012 - Wiley Online Library
Objectives To ascertain the absolute number of M edicare beneficiaries surviving at least 3
years after severe sepsis and to estimate their burden of cognitive dysfunction and disability …

Sepsis: a roadmap for future research

J Cohen, JL Vincent, NKJ Adhikari… - The Lancet infectious …, 2015 - thelancet.com
Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …

Identifying patients with severe sepsis using administrative claims: patient-level validation of the angus implementation of the international consensus conference …

TJ Iwashyna, A Odden, J Rohde, C Bonham… - Medical care, 2014 - journals.lww.com
Background: Severe sepsis is a common and costly problem. Although consistently defined
clinically by consensus conference since 1991, there have been several different …