The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Background Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the
treatment of many cancers. However, doxorubicin posts a great risk of adverse …

Dysregulation of Wnt signaling is closely associated with human liver tumorigenesis.
However, liver cancer-specific Wnt transcriptional programs and downstream effectors …

Growing evidence has shown that a large number of miRNAs are abnormally expressed in
cervical cancer (CC) tissues and play irreplaceable roles in tumorigenesis, progression, and …

The microRNA-26 family, including miR-26a, miR-26b, miR-1297 and miR-4465, is a group
of broadly conserved small RNAs with identical sequences at the seed region. The …

The tripartite motif (TRIM) family is defined by the presence of a Really Interesting New Gene
(RING) domain, one or two B-box motifs and a coiled-coil region. TRIM proteins play key …

Abstract Introduction Autoantibodies to Ro52 recently identified as TRIM21 are among the
most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical …

The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays a critical
role during embryogenesis and is thereafter required for homeostatic glucose metabolism …

Background Cellular senescence is a state of irreversible cell growth arrest and senescence
cells permanently lose proliferation potential. Induction of cellular senescence might be a …