Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise
three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme …

The Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing conversion of
pyruvate to acetyl-CoA comprises three components: E1p, E2p, and E3. The E2p is the five …

The pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle by
converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active …

Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …

The mitochondrial pyruvate dehydrogenase complex (PDC) translocates into the nucleus,
facilitating histone acetylation by producing acetyl-CoA. We describe a noncanonical …

Malaria transmission-blocking vaccines (TBVs) reduce disease transmission by breaking the
continuous cycle of infection between the human host and the mosquito vector. Domain 1 …

Small-angle neutron scattering (SANS) has increasingly been used by the structural biology
community in recent years to obtain low-resolution information on solubilized …

Neutron scattering studies provide important information in structural biology that is not
accessible using other approaches. The uniqueness of the technique, and its …

Cuproptosis is a new mechanism of cell death that differs from previously identified
regulatory cell death mechanisms. Cuproptosis induction holds promise as a new tumour …