[HTML][HTML] Regulation of pyruvate metabolism and human disease
LR Gray, SC Tompkins, EB Taylor - Cellular and molecular life sciences, 2014 - Springer
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …
[HTML][HTML] The pyruvate dehydrogenase complexes: structure-based function and regulation
The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise
three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme …
three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme …
[HTML][HTML] Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex
J Wang, NS Nemeria, K Chandrasekhar… - Journal of Biological …, 2014 - ASBMB
The Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing conversion of
pyruvate to acetyl-CoA comprises three components: E1p, E2p, and E3. The E2p is the five …
pyruvate to acetyl-CoA comprises three components: E1p, E2p, and E3. The E2p is the five …
[HTML][HTML] Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion
J Škerlová, J Berndtsson, H Nolte, M Ott… - Nature …, 2021 - nature.com
The pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle by
converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active …
converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active …
[HTML][HTML] The metabolic fates of pyruvate in normal and neoplastic cells
EV Prochownik, H Wang - Cells, 2021 - mdpi.com
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …
[HTML][HTML] MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex
The mitochondrial pyruvate dehydrogenase complex (PDC) translocates into the nucleus,
facilitating histone acetylation by producing acetyl-CoA. We describe a noncanonical …
facilitating histone acetylation by producing acetyl-CoA. We describe a noncanonical …
[HTML][HTML] A potent and durable malaria transmission-blocking vaccine designed from a single-component 60-copy Pfs230D1 nanoparticle
Malaria transmission-blocking vaccines (TBVs) reduce disease transmission by breaking the
continuous cycle of infection between the human host and the mosquito vector. Domain 1 …
continuous cycle of infection between the human host and the mosquito vector. Domain 1 …
Biological small-angle neutron scattering: recent results and development
E Mahieu, F Gabel - Acta Crystallographica Section D: Structural …, 2018 - journals.iucr.org
Small-angle neutron scattering (SANS) has increasingly been used by the structural biology
community in recent years to obtain low-resolution information on solubilized …
community in recent years to obtain low-resolution information on solubilized …
Biomolecular deuteration for neutron structural biology and dynamics
M Haertlein, M Moulin, JM Devos, V Laux… - Methods in …, 2016 - Elsevier
Neutron scattering studies provide important information in structural biology that is not
accessible using other approaches. The uniqueness of the technique, and its …
accessible using other approaches. The uniqueness of the technique, and its …
[HTML][HTML] DLAT is a promising prognostic marker and therapeutic target for hepatocellular carcinoma: a comprehensive study based on public databases
P Zhang, JH Zhao, LX Yuan, LL Ju, HX Wang… - Scientific Reports, 2023 - nature.com
Cuproptosis is a new mechanism of cell death that differs from previously identified
regulatory cell death mechanisms. Cuproptosis induction holds promise as a new tumour …
regulatory cell death mechanisms. Cuproptosis induction holds promise as a new tumour …