Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium
arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of …

Vascular smooth muscle cells (VSMCs) are an important source of foam cells in
atherosclerosis. The mechanism for VSMC-derived foam cell formation is, however, poorly …

Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease.
Foam cell, a hallmark of atherosclerosis, is prominently derived from monocyte-differentiated …

ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis.
Their anti-atherogenic potential has been attributed to their role in the inhibition of …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Every organism has an intrinsic biological rhythm that orchestrates biological processes in
adjusting to daily environmental changes. Circadian rhythms are maintained by networks of …

Dyslipidemia is a main driver of cardiovascular diseases. The ability of macrophages to
scavenge excess lipids implicate them as mediators in this process and understanding the …