The curious case of the HepG2 cell line: 40 years of expertise

VA Arzumanian, OI Kiseleva… - International journal of …, 2021 - mdpi.com
Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

Inflammatory effects of hexavalent chromium in the lung: A comprehensive review

JC Kouokam, I Meaza, JP Wise Sr - Toxicology and applied pharmacology, 2022 - Elsevier
Besides smoking, lung cancer can be caused by other factors, including heavy metals such
as cadmium, nickel, arsenic, beryllium and hexavalent chromium [Cr (VI)], which is used in …

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

H Tseng, W Xiong, S Badeti, Y Yang, M Ma… - Nature …, 2020 - nature.com
Chimeric antigen receptor (CAR) therapy is a promising immunotherapeutic strategy for
treating multiple refractory blood cancers, but further advances are required for solid tumor …

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

J Feng, W Dai, Y Mao, L Wu, J Li, K Chen, Q Yu… - Journal of Experimental …, 2020 - Springer
Background Hepatocellular carcinoma (HCC) is a common primary malignant tumor which
usually progresses to an advanced stage because of late diagnosis. Sorafenib (Sora) is a …

Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

J Fang, S Singh, C Cheng, S Natarajan… - Nature …, 2023 - nature.com
A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …

PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

Y Shi, Y Niu, Y Yuan, K Li, C Zhong, Z Qiu, K Li… - Nature …, 2023 - nature.com
Although oxaliplatin-based chemotherapy has been effective in the treatment of
hepatocellular carcinoma (HCC), primary or acquired resistance to oxaliplatin remains a …

Targeting alpha-fetoprotein (AFP)–MHC complex with CAR T-cell therapy for liver cancer

H Liu, Y Xu, J Xiang, L Long, S Green, Z Yang… - Clinical cancer …, 2017 - AACR
Purpose: The majority of tumor-specific antigens are intracellular and/or secreted and
therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy …

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

M Eichenmüller, F Trippel, M Kreuder, A Beck… - Journal of …, 2014 - Elsevier
Background & Aims Hepatoblastoma (HB) is the most common childhood liver cancer and
occasionally presents with histological and clinical features reminiscent of hepatocellular …

[HTML][HTML] Roles of endoplasmic reticulum stress and autophagy on H2O2‑induced oxidative stress injury in HepG2 cells

Z Wu, H Wang, S Fang, C Xu - Molecular medicine …, 2018 - spandidos-publications.com
Endoplasmic reticulum stress (ERS) can be induced by a variety of physiological and
pathological factors including oxidative stress, which triggers the unfolded protein response …

Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma

H Julich-Haertel, SK Urban, M Krawczyk, A Willms… - Journal of …, 2017 - Elsevier
Background & Aims Large extracellular vesicles, specifically AnnexinV+ EpCAM+ CD147+
tumour-associated microparticles (taMPs), facilitate the detection of colorectal carcinoma …