The majority of acquired hearing loss, including presbycusis, is caused by irreversible
damage to the sensorineural tissues of the cochlea. This article reviews the intracellular …

Modern research has provided new in-sights into the biological mechanisms of noise-
induced hearing loss, and with these new insights comes hope for possible prevention or …

Hearing loss caused by exposure to recreational and occupational noise remains a
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …

Programmed cell death (PCD)—apoptosis, autophagy and programmed necrosis—is any
pathological form of cell death mediated by intracellular processes. Ototoxic drugs, ageing …

Recent research has shown the essential role of reduced blood flow and free radical
formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and …

Background Acquired hearing loss is highly prevalent, but prospective data on potentially
modifiable risk factors are limited. In cross-sectional studies, higher body mass index (BMI) …

Free radical formation in the cochlea plays a key role in the development of noise-induced
hearing loss (NIHL). The amount, distribution, and time course of free radical formation have …

The mechanisms of sensory hair cell degeneration in response to different ototoxic stimuli
share a final common pathway: caspase activation. Inhibition of caspases prevents or delays …

Nitrones have the general chemical formula X–CH= NO–Y. They were first used to trap free
radicals in chemical systems and then subsequently in biochemical systems. More recently …

Noise-induced hearing loss (NIHL) is the leading occupational disease and a major
contributor to the development of age-related hearing loss. The pharmacological prevention …