Modeling the within-host dynamics of HIV infection

AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …

Transmission, acute HIV-1 infection and the quest for strategies to prevent infection

M Pope, AT Haase - Nature medicine, 2003 - nature.com
By the acute stage of HIV-1 infection, the immune system already faces daunting challenges.
Research on mucosal barriers and the events immediately after heterosexual transmission …

Mathematical analysis of HIV-1 dynamics in vivo

AS Perelson, PW Nelson - SIAM review, 1999 - SIAM
Mathematical models have proven valuable in understanding the dynamics of HIV-1
infection in vivo. By comparing these models to data obtained from patients undergoing …

Modeling the mechanics of viral kinetics under immune control during primary infection of HIV-1 with treatment in fractional order

PA Naik, J Zu, KM Owolabi - Physica A: statistical mechanics and its …, 2020 - Elsevier
In this paper, we propose and analyze a fractional order model of viral kinetics for primary
infection of HIV-1 in presence of immune control with treatment, as the classical model of …

A delay-differential equation model of HIV infection of CD4+ T-cells

RV Culshaw, S Ruan - Mathematical biosciences, 2000 - Elsevier
AS Perelson, DE Kirschner and R. De Boer (Math. Biosci. 114 (1993) 81) proposed an ODE
model of cell-free viral spread of human immunodeficiency virus (HIV) in a well-mixed …

Modeling plasma virus concentration during primary HIV infection

MA Stafford, L Corey, Y Cao, ES Daar, DD Ho… - Journal of theoretical …, 2000 - Elsevier
During primary HIV infection the viral load in plasma increases, reaches a peak, and then
declines. Phillips has suggested that the decline is due to a limitation in the number of cells …

HIV-1 infection and low steady state viral loads

DS Callaway, AS Perelson - Bulletin of mathematical biology, 2002 - Elsevier
Highly active antiretroviral therapy (HAART) reduces the viral burden in human
immunodeficiency virus type 1 (HIV-1) infected patients below the threshold of detectability …

Perils at mucosal front lines for HIV and SIV and their hosts

AT Haase - Nature Reviews Immunology, 2005 - nature.com
HIV-1 and simian immunodeficiency virus (SIV), as well as their hosts, face perils at mucosal
front lines in early infection. At these sites,'resting'CD4+ memory T cells fuel infection …

Modeling HIV-1 virus dynamics with both virus-to-cell infection and cell-to-cell transmission

X Lai, X Zou - SIAM Journal on Applied Mathematics, 2014 - SIAM
Direct cell-to-cell transfer of HIV-1 is found to be a more potent and efficient means of virus
propagation than virus-to-cell infection. In this paper we propose a mathematical model to …

Parasite adaptations to within-host competition

N Mideo - Trends in parasitology, 2009 - cell.com
Competition between parasite species or strains within hosts is a major evolutionary force in
infections. In response, parasites exhibit a diverse array of strategies that improve their …