Molecular mechanisms of two-component signal transduction
CP Zschiedrich, V Keidel, H Szurmant - Journal of molecular biology, 2016 - Elsevier
Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …
proteins are among the most important players in bacterial and archaeal signal transduction …
Emerging methods in protein co-evolution
Co-evolution is a fundamental component of the theory of evolution and is essential for
understanding the relationships between species in complex ecological networks. A wide …
understanding the relationships between species in complex ecological networks. A wide …
Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information
S Ovchinnikov, H Kamisetty, D Baker - elife, 2014 - elifesciences.org
Do the amino acid sequence identities of residues that make contact across protein
interfaces covary during evolution? If so, such covariance could be used to predict contacts …
interfaces covary during evolution? If so, such covariance could be used to predict contacts …
Direct-coupling analysis of residue coevolution captures native contacts across many protein families
The similarity in the three-dimensional structures of homologous proteins imposes strong
constraints on their sequence variability. It has long been suggested that the resulting …
constraints on their sequence variability. It has long been suggested that the resulting …
Protein 3D structure computed from evolutionary sequence variation
The evolutionary trajectory of a protein through sequence space is constrained by its
function. Collections of sequence homologs record the outcomes of millions of evolutionary …
function. Collections of sequence homologs record the outcomes of millions of evolutionary …
Improved contact prediction in proteins: using pseudolikelihoods to infer Potts models
Spatially proximate amino acids in a protein tend to coevolve. A protein's three-dimensional
(3D) structure hence leaves an echo of correlations in the evolutionary record. Reverse …
(3D) structure hence leaves an echo of correlations in the evolutionary record. Reverse …
Are biological systems poised at criticality?
Many of life's most fascinating phenomena emerge from interactions among many elements—
many amino acids determine the structure of a single protein, many genes determine the …
many amino acids determine the structure of a single protein, many genes determine the …
Inverse statistical physics of protein sequences: a key issues review
In the course of evolution, proteins undergo important changes in their amino acid
sequences, while their three-dimensional folded structure and their biological function …
sequences, while their three-dimensional folded structure and their biological function …
Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1
M Figliuzzi, H Jacquier, A Schug… - Molecular biology …, 2016 - academic.oup.com
The quantitative characterization of mutational landscapes is a task of outstanding
importance in evolutionary and medical biology: It is, for example, of central importance for …
importance in evolutionary and medical biology: It is, for example, of central importance for …
Emerging computational methods for the rational discovery of allosteric drugs
Allosteric drug development holds promise for delivering medicines that are more selective
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …