Role of AMPK in autophagy

S Wang, H Li, M Yuan, H Fan, Z Cai - Frontiers in physiology, 2022 - frontiersin.org
Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …

Autophagy in health and disease: From molecular mechanisms to therapeutic target

G Lu, Y Wang, Y Shi, Z Zhang, C Huang, W He… - MedComm, 2022 - Wiley Online Library
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

SIRT1 and autophagy: implications in endocrine disorders

JY Kim, D Mondaca-Ruff, S Singh… - Frontiers in …, 2022 - frontiersin.org
Autophagy is a cellular process involved in the selective degradation and recycling of
dysfunctional intracellular components. It plays a crucial role in maintaining cellular …

Defective lysosome reformation during autophagy causes skeletal muscle disease

MJ McGrath, MJ Eramo, R Gurung… - The Journal of …, 2021 - Am Soc Clin Investig
The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We
showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic …

Autophagy dysregulation in diabetic kidney disease: from pathophysiology to pharmacological interventions

CD Gonzalez, MP Carro Negueruela… - Cells, 2021 - mdpi.com
Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes
mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic …

Secretory autophagy and its relevance in metabolic and degenerative disease

CD Gonzalez, R Resnik, MI Vaccaro - Frontiers in endocrinology, 2020 - frontiersin.org
Proteins to be secreted through so-called “conventional mechanisms” are characterized by
the presence of an N-terminal peptide that is a leader or signal peptide, needed for access …

ATG9A regulates the dissociation of recycling endosomes from microtubules to form liquid influenza A virus inclusions

S Vale-Costa, TA Etibor, D Brás, AL Sousa… - PLoS …, 2023 - journals.plos.org
It is now established that many viruses that threaten public health establish condensates via
phase transitions to complete their lifecycles, and knowledge on such processes may offer …

Mind the gap: Mitochondria and the endoplasmic reticulum in neurodegenerative diseases

NS Leal, LM Martins - Biomedicines, 2021 - mdpi.com
The way organelles are viewed by cell biologists is quickly changing. For many years, these
cellular entities were thought to be unique and singular structures that performed specific …

Autophagy in inflammatory response against SARS-CoV-2

R Resnik, F Lopez Mingorance, F Rivera… - International Journal of …, 2023 - mdpi.com
The coronavirus disease pandemic, which profoundly reshaped the world in 2019 (COVID-
19), and is currently ongoing, has affected over 200 countries, caused over 500 million …

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

B Binotti, M Ninov, AP Cepeda, M Ganzella, U Matti… - Autophagy, 2024 - Taylor & Francis
In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by
maturation during retrograde transport. Autophagosomal growth depends on the supply of …