Mechanochemistry: new tools to navigate the uncharted territory of “impossible” reactions

F Cuccu, L De Luca, F Delogu, E Colacino… - …, 2022 - Wiley Online Library
Mechanochemical transformations have made chemists enter unknown territories, forcing a
different chemistry perspective. While questioning or revisiting familiar concepts belonging …

The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

How to approach flow chemistry

M Guidi, PH Seeberger, K Gilmore - Chemical Society Reviews, 2020 - pubs.rsc.org
Flow chemistry is a widely explored technology whose intrinsic features both facilitate and
provide reproducible access to a broad range of chemical processes that are otherwise …

Electrochemical dearomative dicarboxylation of heterocycles with highly negative reduction potentials

Y You, W Kanna, H Takano, H Hayashi… - Journal of the …, 2022 - ACS Publications
The dearomative dicarboxylation of stable heteroaromatics using CO2 is highly challenging
but represents a very powerful method for producing synthetically useful dicarboxylic acids …

Taming hazardous chemistry by continuous flow technology

M Movsisyan, EIP Delbeke, J Berton… - Chemical Society …, 2016 - pubs.rsc.org
Over the last two decades, flow technologies have become increasingly popular in the field
of organic chemistry, offering solutions for engineering and/or chemical problems. Flow …

Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …

Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow

H Seo, MH Katcher, TF Jamison - Nature chemistry, 2017 - nature.com
Although carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in
chemical synthesis. In particular, methods for carbon–carbon bond formation generally rely …

Organic synthesis: march of the machines

SV Ley, DE Fitzpatrick, RJ Ingham… - Angewandte Chemie …, 2015 - Wiley Online Library
Organic synthesis is changing; in a world where budgets are constrained and the
environmental impacts of practice are scrutinized, it is increasingly recognized that the …

The use of gases in flow synthesis

CJ Mallia, IR Baxendale - Organic Process Research & …, 2016 - ACS Publications
This review will highlight the potential benefits that can be leveraged by using flow chemistry
to allow gases to be used in research in a safer and more efficient way. An overview of the …

Safety assessment in development and operation of modular continuous-flow processes

N Kockmann, P Thenée, C Fleischer-Trebes… - Reaction Chemistry & …, 2017 - pubs.rsc.org
Improved safety is one of the main drivers for microreactor application in chemical process
development and small-scale production. Typical examples of hazardous chemistry are …