Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Autophagy, a conserved catabolic process, plays an immensely significant role in a variety
of diseases. However, whether it imparts a protective function in diseases remains …

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

The endoplasmic reticulum (ER) is a multifunctional organelle within which protein folding,
lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient …

Environmental exposure to silica nanoparticles (SiNPs) is inevitable due to their widespread
application in industrial, commercial, and biomedical fields. In recent years, most …

Chronic stress can affect human health through a myriad of behavioral and biochemical
pathways. This review focuses on some key hormonal and metabolic pathways that appear …

Brain aging is linked to certain types of neurodegenerative diseases and identifying new
therapeutic targets has become critical. Melatonin, a pineal hormone, associates with …

The lysosomal network is the major intracellular proteolytic system accounting for more than
98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver …

Atherosclerosis is a multifactorial, multistep disorder of large‐and medium‐sized arteries
involving, in addition to age, gender and menopausal status, a complex interplay between …

Cognitive impairment and neurodegeneration still occur despite highly active antiretroviral
therapy (HAART). While there are many potential reasons for this, there is increasing …