[HTML][HTML] Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …

Recent advances in treating female genital human papillomavirus related neoplasms with topical imiquimod

F Borella, N Gallio, L Mangherini… - Journal of Medical …, 2023 - Wiley Online Library
Human papillomavirus (HPV) encompasses a group of viruses that infect the skin and
mucous membranes. In the presence of certain factors, persistent infection with high‐risk …

Risk factors associated with HPV persistence after conization in high-grade squamous intraepithelial lesion

L Zang, Y Hu - Archives of gynecology and obstetrics, 2021 - Springer
Objective Persistence of HPV infection in patients with high-grade squamous intraepithelial
lesion (HSIL) undergoing cervical excision is considered strongly associated with the …

[HTML][HTML] Topical imiquimod compared with conization to treat cervical high-grade squamous intraepithelial lesions: Multicenter, randomized controlled trial

S Polterauer, O Reich, A Widschwendter, L Hadjari… - Gynecologic …, 2022 - Elsevier
Objective In a previous phase II trial, we showed that topical imiquimod (IMQ) therapy is an
efficacious treatment for high-grade squamous intraepithelial lesion (HSIL). Aim of the …

[HTML][HTML] “There is nothing that can prevent me from supporting her:” Men's perspectives on their involvement and support of women's use of topical therapy for cervical …

C Mungo, K Adewumi, E Adoyo, G Zulu… - Frontiers in …, 2024 - frontiersin.org
Purpose Cervical cancer disproportionately impacts women in low-and middle-income
countries (LMICs). The World Health Organization's (WHO) 90/70/90 strategy aims to …

[HTML][HTML] Innovative diagnostic and therapeutic interventions in cervical dysplasia: a systematic review of controlled trials

JM Hecken, GA Rezniczek, CB Tempfer - Cancers, 2022 - mdpi.com
Simple Summary Cervical dysplasia is one of the most common disorders of the female
genital tract affecting millions of women worldwide. This systematic review of the literature of …

Feasibility of 5‐fluorouracil and imiquimod for the topical treatment of cervical intraepithelial neoplasias (CIN) 2/3

N Desravines, CH Hsu, S Mohnot… - … of Gynecology & …, 2023 - Wiley Online Library
Objectives To determine the feasibility (as measured by tolerability and safety) and efficacy
of topical 5‐fluorouracil (5‐FU) and imiquimod for the treatment of cervical intraepithelial …

[HTML][HTML] Importance of the immune microenvironment in the spontaneous regression of cervical squamous intraepithelial lesions (cSIL) and implications for …

CLP Muntinga, PJ de Vos van Steenwijk… - Journal of Clinical …, 2022 - mdpi.com
Cervical high-grade squamous intraepithelial lesions (cHSILs) develop as a result of a
persistent high-risk human papilloma virus (hrHPV) infection. The natural course of cHSIL is …

Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions

J Ye, L Zheng, Y He, X Qi - MedComm, 2023 - Wiley Online Library
Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally.
Persistent high‐risk HPV infection can result in cervical precancerous lesions and cervical …

[HTML][HTML] A gene signature identifying CIN3 regression and cervical cancer survival

MK Halle, AC Munk, B Engesæter, S Akbari, A Frafjord… - Cancers, 2021 - mdpi.com
Simple Summary Through implementation of HPV testing as standard primary screening
method, the number of women diagnosed with high-grade cervical intraepithelial neoplasia …