Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …

Centromeres are the specialized regions of the chromosomes that direct faithful
chromosome segregation during cell division. Despite their functional conservation …

Kinetochore is an essential protein complex required for accurate chromosome segregation.
The constitutive centromere-associated network (CCAN), a subcomplex of the kinetochore …

Kinetochores are large protein complexes built on centromeric chromatin that mediate
chromosome segregation. The inner kinetochore, or constitutive centromere-associated …

The structural organization of the genome is emerging as a crucial regulator of the cell state,
affecting gene transcription, DNA replication, and repair. Over the last twenty years …

Centromeres are scaffolds for the assembly of kinetochores that ensure chromosome
segregation during cell division. How vertebrate centromeres obtain a three-dimensional …

The centromere components cohesin, CENP-A, and centromeric DNA are essential for
biorientation of sister chromatids on the mitotic spindle and accurate sister chromatid …

Centromeres are essential loci in eukaryotes that are necessary for the faithful segregation
of chromosomes in mitosis and meiosis. Centromeres organize the kinetochore, the protein …

Centromeres play a key role in the maintenance of genome stability to prevent
carcinogenesis and diseases. They are specialized chromosome loci essential to ensure …