The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor
antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of
tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in …

Liver fibrosis is a consequence of chronic liver disease, causing morbidity and mortality.
Interleukin-33 (IL-33) is a critical mediator of inflammation, which may be involved in the …

Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which the lungs become
irreversibly scarred, leading to declining lung function. As currently available drugs do not …

Background Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33,
thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role …

Paraquat is a highly toxic herbicide that selectively accumulates in the lungs and causes
pulmonary damage through the oxidative and inflammatory processes. Carvedilol is a …

The intricate relationship between severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) and the cardiovascular system is an extensively studied pandemic topic, as there is …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD)
with limited treatment options. Interleukin-33 (IL-33) is proposed to play a role in the …

Abstract Interleukin-33 (IL-33) which belongs to the interleukin-1 (IL-1) family is an alarmin
cytokine with critical roles in tissue homeostasis, pathogenic infection, inflammation, allergy …

IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the
nucleus of cells where it plays a role in gene regulation. Given the right combination of …