Possibly of all the common phospholipids, least is known about plasmalogens. Although
plasmalogens represent one in every five phospholipids in the human body, one would be …

▪ Abstract Platelet-activating factor (PAF) is a phospholipid with potent, diverse physiological
actions, particularly as a mediator of inflammation. The synthesis, transport, and degradation …

The development of mass spectrometry-based techniques is opening new insights into the
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …

Platelet-activating factor is a phospholipid with diverse potent physiological effects. Its
actions are achieved at concentrations as low as IO-'” M in some systems and almost always …

Professional phagocytes (neutrophils, eosinophils, monocytes and macrophages) possess
an enzymatic complex, the NADPH oxidase, which is able to catalyze the one‐electron …

Numerous studies have indicated that the fatty acids of cellular phospholipids are distributed
asymmetrically. In general, saturated fatty acids are esterified at the sn-1 position while …

Over the past few decades, the fundamental concept that the in vivo modulation of levels of
arachidonic acid (AA) is intimately linked to cellular function and human disease has been …

Lipids orchestrate biological processes by acting remotely as signaling molecules or locally
as membrane components that modulate protein function. Detailed insight into lipid function …

Phospholipase A 2 s generate lipid mediators that constitute an important component of the
integrated response of macrophages to stimuli of the innate immune response. Because …

The superoxide-producing phagocyte NADPH oxidase can be activated by arachidonic acid
(AA) or by phosphorylation of p47 phox under cell-free conditions. The molecular …