Use of zebrafish in drug discovery toxicology
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …
health and money. The drug discovery industry attempts to minimize those events with …
Endometriosis and medical therapy: from progestogens to progesterone resistance to GnRH antagonists: a review
J Donnez, MM Dolmans - Journal of Clinical Medicine, 2021 - mdpi.com
Background: The first objective of this review was to present, based on recent literature, the
most frequently applied medical options (oral contraceptive pills (OCPs) and progestogens) …
most frequently applied medical options (oral contraceptive pills (OCPs) and progestogens) …
Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …
pose a risk to ecosystems and human health. This contamination cannot be addressed with …
Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
Thousands of organic micropollutants and their transformation products occur in water.
Although often present at low concentrations, individual compounds contribute to mixture …
Although often present at low concentrations, individual compounds contribute to mixture …
Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the …
Abstract Effect-based methods including cell-based bioassays, reporter gene assays and
whole-organism assays have been applied for decades in water quality monitoring and …
whole-organism assays have been applied for decades in water quality monitoring and …
Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water
Surface waters can contain a diverse range of organic pollutants, including pesticides,
pharmaceuticals and industrial compounds. While bioassays have been used for water …
pharmaceuticals and industrial compounds. While bioassays have been used for water …
[HTML][HTML] Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills
RF Casper - Fertility and sterility, 2017 - Elsevier
For decades, combined estrogen-progestin oral contraceptive pills (OCPs) have been the
first-line treatment for menstrual and pelvic pain associated with endometriosis without any …
first-line treatment for menstrual and pelvic pain associated with endometriosis without any …
In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays
V Le Fol, S Aït-Aïssa, M Sonavane, JM Porcher… - Ecotoxicology and …, 2017 - Elsevier
Bisphenol A (BPA) is a widely used chemical that has been extensively studied as an
endocrine-disrupting chemical (EDC). Other bisphenols sharing close structural features …
endocrine-disrupting chemical (EDC). Other bisphenols sharing close structural features …
Future water quality monitoring—Adapting tools to deal with mixtures of pollutants in water resource management
Environmental quality monitoring of water resources is challenged with providing the basis
for safeguarding the environment against adverse biological effects of anthropogenic …
for safeguarding the environment against adverse biological effects of anthropogenic …
The fish embryo test (FET): origin, applications, and future
T Braunbeck, B Kais, E Lammer, J Otte… - … Science and Pollution …, 2015 - Springer
Originally designed as an alternative for the acute fish toxicity test according to, eg, OECD
TG 203, the fish embryo test (FET) with the zebrafish (Danio rerio) has been optimized …
TG 203, the fish embryo test (FET) with the zebrafish (Danio rerio) has been optimized …