Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

In recent years, breakthroughs in bioinformatics have been made with the discovery of many
functionally significant non-coding RNAs (ncRNAs). The discovery of these ncRNAs has …

Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …

Circular RNA (circRNA) is an intriguing class of RNA with covalently closed-loop structure
and is highly stable and conservative. As new members of the ncRNAs, the function …

Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research
field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to …

Advances in high-throughput sequencing techniques and bioinformatic analysis have
refuted the “junk” RNA hypothesis that was claimed against non-coding RNAs (ncRNAs) …

Introduction Hypoxia and tumor-associated macrophage (TAM) are key regulators in
remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC) …

Abstract circular RNA ciRS-7 (ciRS-7) is a type of endogenous circular RNA (circRNA) with a
closed circular structure. Since Hansen first demonstrated that ciRS-7 could serve as a …

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to
indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a …

Nuclear factor-κB (NF-κB) represents a group of inducible transcription factors (TFs)
regulating the expression of a great variety of genes implicated in diverse processes …