Application of alginate hydrogels for next-generation articular cartilage regeneration
The articular cartilage has insufficient intrinsic healing abilities, and articular cartilage
injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials …
injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials …
The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review
A Goldberg, K Mitchell, J Soans, L Kim… - Journal of orthopaedic …, 2017 - Springer
Background The management of articular cartilage defects presents many clinical
challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation …
challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation …
Hydrogels as extracellular matrices for skeletal tissue engineering: state-of-the-art and novel application in organ printing
NE Fedorovich, J Alblas, JR de Wijn… - Tissue …, 2007 - liebertpub.com
Organ printing, a novel approach in tissue engineering, applies layered computer-driven
deposition of cells and gels to create complex 3-dimensional cell-laden structures. It shows …
deposition of cells and gels to create complex 3-dimensional cell-laden structures. It shows …
Major biological obstacles for persistent cell-based regeneration of articular cartilage
AF Steinert, SC Ghivizzani, A Rethwilm… - Arthritis research & …, 2007 - Springer
Hyaline articular cartilage, the load-bearing tissue of the joint, has very limited repair and
regeneration capacities. The lack of efficient treatment modalities for large chondral defects …
regeneration capacities. The lack of efficient treatment modalities for large chondral defects …
Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy
MV Risbud, TJ Albert, A Guttapalli, EJ Vresilovic… - Spine, 2004 - journals.lww.com
Objective. Because mesenchymal stem cells can differentiate into chondrocyte-like cells, we
ask the question, can mesenchymal stem cells commit to the nucleus pulposus phenotype …
ask the question, can mesenchymal stem cells commit to the nucleus pulposus phenotype …
Cartilage repair using bone morphogenetic protein 4 and muscle‐derived stem cells
R Kuroda, A Usas, S Kubo, K Corsi… - … : Official Journal of …, 2006 - Wiley Online Library
Objective Muscle‐derived stem cells (MDSCs) isolated from mouse skeletal muscle exhibit
long‐time proliferation, high self‐renewal, and multipotent differentiation. This study was …
long‐time proliferation, high self‐renewal, and multipotent differentiation. This study was …
Directing stem cell differentiation into the chondrogenic lineage in vitro
A major area in regenerative medicine is the application of stem cells in cartilage tissue
engineering and reconstructive surgery. This requires well‐defined and efficient protocols …
engineering and reconstructive surgery. This requires well‐defined and efficient protocols …
Biomaterials and scaffold design: key to tissue‐engineering cartilage
J Raghunath, J Rollo, KM Sales… - Biotechnology and …, 2007 - Wiley Online Library
Cartilage remains one of the most challenging tissues to reconstruct or replace, owing to its
complex geometry in facial structures and mechanical strength at articular surfaces in joints …
complex geometry in facial structures and mechanical strength at articular surfaces in joints …
Chemotaxis of human articular chondrocytes and mesenchymal stem cells
Y Mishima, M Lotz - Journal of Orthopaedic Research, 2008 - Wiley Online Library
Migration of chondrocytes and mesenchymal stem cells (MSCs) may be important in
cartilage development, tissue response to injury, and in tissue engineering. This study …
cartilage development, tissue response to injury, and in tissue engineering. This study …
Chondrogenic differentiation of human mesenchymal stem cells in collagen type I hydrogels
U Nöth, L Rackwitz, A Heymer, M Weber… - … Research Part A: An …, 2007 - Wiley Online Library
The chondrogenic differentiation of bone marrow‐derived human mesenchymal stem cells
(MSCs) in a collagen type I hydrogel, which is in clinical use for matrix‐based autologous …
(MSCs) in a collagen type I hydrogel, which is in clinical use for matrix‐based autologous …