A brief review of reporter gene imaging in oncolytic virotherapy and gene therapy

SJ Russell, KW Peng - Molecular Therapy-Oncolytics, 2021 - cell.com
Reporter gene imaging (RGI) can accelerate development timelines for gene and viral
therapies by facilitating rapid and noninvasive in vivo studies to determine the …

Challenges in neuroprotective nanomedicine development: progress towards noninvasive gene therapy of glaucoma

S Alqawlaq, JT Huzil, MV Ivanova, M Foldvari - Nanomedicine, 2012 - Taylor & Francis
Over the past decade the application of gene therapy of retinal diseases such as glaucoma
has produced promising results. However, optic nerve regeneration and restoration of vision …

The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age

LC Byrne, YJ Lin, T Lee, DV Schaffer, JG Flannery - Molecular Therapy, 2015 - cell.com
Systemic delivery of AAV9 offers the potential for widespread and efficient gene delivery to
the retina, and may thus be a useful approach for treatment of disease where intraocular …

A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina

AP Bemelmans, S Duqué, C Rivière, S Astord… - PLoS …, 2013 - journals.plos.org
Widespread gene delivery to the retina is an important challenge for the treatment of retinal
diseases, such as retinal dystrophies. We and others have recently shown that the …