GPR84 was first identified as an open reading frame encoding an orphan Class AG protein
coupled receptor in 2001. Gpr84 mRNA is expressed in a limited number of cell types with …

Persistent inflammation in damaged joints results in metabolic dysregulation of the synovial
microenvironment, causing pathogenic alteration of cell activity in rheumatoid arthritis (RA) …

Methods The role and underlying mechanism that MDSCs or exosomes (Exo) regulates the
function of CD8+ T cells were investigated using immunofluorescence, fluorescence …

GPR84 is a putative medium-chain fatty acid receptor that is implicated in regulation of
inflammation and fibrogenesis. Studies have indicated that GPR84 agonists may have …

Orphan G-protein-coupled receptor 84 (GPR84) is a receptor that has been linked to cancer,
inflammatory, and fibrotic diseases. We have reported DL-175 as a biased agonist at GPR84 …

In recent years, the therapeutic (re) activation of innate anticancer immunity has gained
prominence, with therapeutic blocking of the interaction of Signal Regulatory Protein (SIRP) …

Amyloid β (Aβ) forms aggregates in the Alzheimer's disease brain and is well known for its
pathological roles. Recent studies show that it also regulates neuronal physiology in the …

Recent evidence has highlighted the detrimental effects of fatty acid receptor dysfunction in
the lung, with a major focus on the roles of short-and long-chain fatty acid receptors and …

G protein-coupled receptor 84 (GPR84) was cloned as an orphan receptor, and medium-
chain fatty acids were then revealed as endogenous ligands. GPR84 is expressed in …

Neurodegenerative disorders, particularly Alzheimer's and Parkinson's diseases, continue to
challenge modern medicine despite therapeutic advances. Orphan G-protein-coupled …