The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

It is widely accepted that the gut microbiota plays a significant role in modulating
inflammatory and immune responses of their host. In recent years, the host-microbiota …

Osteoporotic fracture is among the most common and costly of diseases. While reasonably
heritable, its genetic determinants have remained elusive. Forearm fractures are the most …

Aims: This systematic review examines the association between maternal lifestyle, diet and
physical activity, and epigenetic changes in the offspring. Methods: A literature search was …

Malic Enzyme 1 (ME1) supports lipogenesis, cholesterol synthesis, and cellular redox
potential by catalyzing the decarboxylation of L-malate to pyruvate, and the concomitant …

Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR) are involved in
multiple physiological systems related to glucose metabolism, bone homeostasis and fat …

Purpose The causal relationships between circulating adipokines and idiopathic pulmonary
fibrosis (IPF) are yet to be established. We performed a two-sample Mendelian …

Leptin is an adipokine that regulates appetite and body mass and has many other
pleiotropic functions, including regulating kidney function. Increased evidence shows that …

Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system
confer a risk for monogenic forms of obesity. Yet, gain of function variants in the …

Early childhood obesity is a growing global concern; however, the role of common genetic
variation on infant and child weight development is unclear. Here, we identify 46 loci …