Lactobacillus rhamnosus LRa05 Ameliorate Hyperglycemia through a Regulating Glucagon-Mediated Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice
In this study, we aimed to explore the antidiabetic effects of Lactobacillus rhamnosus LRa05
on glucose metabolism and gut microbiota in type 2 diabetes mellitus (T2DM) mice. Our data …
on glucose metabolism and gut microbiota in type 2 diabetes mellitus (T2DM) mice. Our data …
The role of glucagon in glycemic variability in type 1 diabetes: a narrative review
K Guo, Q Tian, L Yang, Z Zhou - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Type 1 diabetes mellitus (T1DM) is a progressive disease as a result of the severe
destruction of islet β-cell function, which leads to high glucose variability in patients …
destruction of islet β-cell function, which leads to high glucose variability in patients …
A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine …
A Martin, GJ Mick, HM Choat, AA Lunsford… - Nature …, 2022 - nature.com
Gamma aminobutyric acid (GABA) is synthesized by glutamate decarboxylase (GAD) in β-
cells. Regarding Type 1 diabetes (T1D), animal/islet-cell studies found that GABA promotes …
cells. Regarding Type 1 diabetes (T1D), animal/islet-cell studies found that GABA promotes …
Lactobacillus casei LC89 exerts antidiabetic effects through regulating hepatic glucagon response and gut microbiota in type 2 diabetic mice
Previous study suggests that Lactobacillus casei exhibits antihyperglycemic activity,
however, the molecular mechanism of this has yet to be elucidated. Here, the anti-diabetic …
however, the molecular mechanism of this has yet to be elucidated. Here, the anti-diabetic …
Recent drug development of dorzagliatin, a new glucokinase activator, with the potential to treat Type 2 diabetes: A review study
Y Jiang, L Wang, Z Dong, B Xia, S Pang - Journal of Diabetes, 2024 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a complicated disease related to metabolism that results
from resistance to insulin and sustained hyperglycemia. Traditional antidiabetic drugs …
from resistance to insulin and sustained hyperglycemia. Traditional antidiabetic drugs …
Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance
Aims/hypothesis People with isolated impaired fasting glucose (IFG) have normal beta cell
function. We hypothesised that an increased glucose threshold for beta cell secretion …
function. We hypothesised that an increased glucose threshold for beta cell secretion …
Assessment of individual and standardized glucagon kinetics in healthy humans
MC Laurenti, A Vella, JD Adams… - American Journal …, 2021 - journals.physiology.org
Impaired glucose tolerance arises out of impaired postprandial insulin secretion and
delayed suppression of glucagon. These defects occur early and independently in the …
delayed suppression of glucagon. These defects occur early and independently in the …
Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway
J Ji, L Qian, Y Zhu, Y Wu, J Guo, G Ma, Y Yao - Cellular signalling, 2020 - Elsevier
Background Serpina3 is a member of the serine protease inhibitor family and is involved in
the inflammatory response. In this study, we investigated the effect of Serpina3c on …
the inflammatory response. In this study, we investigated the effect of Serpina3c on …
Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling
J Song, Q He, X Guo, L Wang, J Wang, C Cui… - Molecular and Cellular …, 2021 - Elsevier
Background α-cell dysregulation gives rise to fasting and postprandial hyperglycemia in type
2 diabetes mellitus (T2DM). Administration of Mesenchymal stem cells (MSCs) or their …
2 diabetes mellitus (T2DM). Administration of Mesenchymal stem cells (MSCs) or their …
Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects …
T Pixner, T Chaikouskaya, W Lauth… - Frontiers in …, 2024 - frontiersin.org
Background Fasting levels of glucagon are known to be elevated in youth and adults with
type 2 diabetes mellitus (T2D). Children and adolescents with obesity were previously …
type 2 diabetes mellitus (T2D). Children and adolescents with obesity were previously …